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- Sebastian Saavedra
- Pasquale Di Sabantino
- Pasquale Di Sabatino
- Bruno Saby
- Ana Sacadura
- Eddie Sachs
- Blaine Sadler
- David Saelens
- Ken Sager
- Joe Sahlen
- Boris Said
- Carlos Sainz(Jr)
- Filip Salaquarda
- Filip Salaquarda
- Mike Salay
- Eliseo Salazar
- Joe Saldana
- Eric Salignon
- Bob Salisbury
- Vinicio Salmi
- Mika Salo
- Aleksandr Salomatov
- Timo Salonen
- Bob Salter
- Pedro Salvador
- Sam Hanks
- Lam Kam San
- Franks Sanders
- Sonny Sanders
- Tim Sandtler
- Consalvo Sanesi
- Wayne Sankey
- Alessandro Santin
- Clive Santo
- Marco Santos
- Diogo Castro Santos
- Rafael Sarandeses
- Marshall Sargent
- Roscoe Sarles
- Sarno
- Stephane Sarrazin
- Dave Sassaman
- Takuma Sato
- Kimiya Sato
- Peter Sauber
- Cyrille Sauvage
- Angelo Sbordone
- Carl Scarborough
- Ludovico Scarfiotti
- Giorgio Scarlatti
- Michael Schaal
- Bob Schacht
- Daniel Schadenberger
- Ed `Dutch` Schaefer
- Dennis Schaeffer
- Hans Schafer
- Karl Schafer
- Demian Schaffert
- Andreas Schall
- Ralf Schall
- Fredy Scharwiler
- Max zu Schaumburg-Lippe
- Tomas Scheckter
- Jody Scheckter
- Ian Scheckter
- Jens Scheefeldt
- Joachim Scheefeldt
- Johannes Scheid
- Timo Scheider
- Fred Schell
- Harry Schell
- Tim Schenken
- Rolf Schenzer
- Heinz Scherger
- Ernst Scherrer
- Fabian Schiller
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- Bill Schindler
- Uwe Schirrmeister
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- Werner Schlehecker
- Jo Schlesser
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- Josef Schlesser
- Jurgen Schlich
- Joachim Schliesinger
- Walter Schluter
- Gunther Schluter
- Robert Schlünssen
- Frank Schmickler
- Clemens Schmid
- Ted Schmid
- Tony Schmidt
- H.J. Schmidt
- Gunther Schmidt
- Florian Schmidt
- Bernhard Schmittner
- Sabine Schmitz
- Franz Schmoller
- Bernd Schneider
- Louis Schneider
- Peter Schneider
- J. Schneider
- Frank Schneider
- Walter Schneider
- Schneiderov
- Schneiter
- Walter Schoch
- Florian Scholze
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- Gus Schrader
- Dominik Schraml
- Karl-Heinz Schrey
- Wolfgang Schrey
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- Ralf Schumacher
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- Michael Schumacher
- Vern Schuppan
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- Richard Scott
- Glyn Scott
- Lyle Scott
- Dave Scott
- Art Scovell
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- Len Searle
- M. Sears
- Jean Sebilleau
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- Brian Seidel
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- Toni Seiler
- Ants Seiler
- John Seip
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- Al Self
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- Bruno Senna
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- Dorino Serafini
- Gabriele Serblin
- Chico Serra
- Felix Serralles
- Skip Serridge
- Doug Serrurier
- Oriol Servia
- Johnny Servoz-Gavin
- Sam Sessions
- Glenn Seton
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- Johnny Seymour
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- Georgiy Sharonov
- Ryan Sharp
- Scott Sharp
- Chris Shaw
- Wilbur Shaw
- Mickey Shaw
- Brian Shawe-Taylor
- Mike Sheehan
- Smokey Sheeler
- Trevor Sheffield
- Bill Sheffler
- Chris Sheil
- Dan Shelbo(Jr)
- Tony Shelly
- Kirk Shelmerdine
- Steve Shelton
- A.J. Shepherd
- Curtis Sherman
- Roy Sherman
- Jimmy Shield
- Hayanari Shimoda
- W.R. Shipman
- Morris Shirazi
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- Vic Shuter
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- Yuriy Sidorov
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- Siegel
- Jo Siffert
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- Luis Sa Silva
- Simona De Silvestro
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- Fabrizio De Simone
- Gianpiero Simoni
- Hans Simons
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- Paul Simpson
- Alexander Sims
- Eugen Sing
- Barry Singleton
- Sergey Sirotkin
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- Gene Siuzdak
- Ugo Sivocci
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- Ryan Smith
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- Russ Snowberger
- Anton Sobolev
- Moreno Soeprapto
- Kristian Sohlberg
- Bruno Sojka
- Alex Soler-Roig
- Matt Solomon
- Anatoliy Solovyov
- Jock Somervail
- Raymond Sommer
- Michael Soong
- Marco Sorensen
- Sormani
- Nikolay Sorochinskiy
- Vincenzo Sorrentino
- Vincenzo Sospiri
- Joe Sostilio
- Joe Sostillio
- Maria do Rosario Sottomayor
- Andy Soucek
- Marc Sourd
- Stephen South
- Felipe De Souza
- Toby Sowery
- Coenraad Spaemer
- Ned Spath
- Scott Speed
- Kurt Speet
- Jack Speis
- Russell Spence
- Mike Spence
- Bruno Spengler
- Ricardo Sperafico
- Alex Sperafico
- Rodrigo Sperafico
- William Spinks
- Dieter Spoerry
- Tin Sritrai
- Alan Stacey
- Arnold Stafford
- N. Staic
- Friedrich-Wilhelm Stallma
- Richie Stanaway
- Ken Stansbury
- Morrie Stanton
- Norman Starke
- Josef Stasny
- Ray Stauffer
- Walt Stearly
- S.W. Steece
- Tim Steele
- Jim Steele
- Aldo Stefani
- Dave Steffens
- Carl Steffy
- Rico Steinemann
- Ricky Stenhouse(Jr)
- S.A. Stepanov
- John de Stephano
- Max Stephens
- Gig Stephens
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- Stephanie Stevens
- Will Stevens
- Chuck Stevenson
- John Stevenson
- Jackie Stewart
- Max Stewart
- Bruce Stewart
- Paul Stewart
- Tony Stewart(Aust)
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- Bib Stillwell
- Boyd Stilt
- Ed Stimely(Jr)
- Ottis Stine
- Frank Stippler
- Marlon Stockinger
- Spencer Stoddard
- Siegfried Stohr
- Anton Stoiber
- Matthias Stolz
- Rolf Stommelen
- Dean Stoneman
- Ramo Stott
- George van Straaten
- John Stradtman
- Philippe Streiff
- Roberto Streit
- Al Striegel
- Lance Stroll
- Bill Stroppe
- Heinz Stuber
- Hans Stuber
- Hans Stuck
- Hans-Joachim Stuck
- Benjamin Studer
- Matheus Stumpf
- Harry Stumpf-Lekisch
- Al Stumpp
- Sandy Stuvik
- Jurgen Stuwe
- David Suchy
- Brian Suchy
- Aleksandr Sukhovey
- Danny Sullivan
- Tom Sulman
- Jonathan Summerton
- Justin Sunkel
- Dieter Supanz
- Alessandro Suppi
- Marc Surer
- Georgiy Surguchev
- John Surtees
- Yevgeniy Sushynskiy
- Andy Sutcliffe
- Adrian Sutil
- Len Sutton
- Toshio Suzuki
- Aguri Suzuki
- Ted Swain
- Koos Swanepoel
- Brad Sweet
- Bob Sweikert
- Hans-Peter Syfrig
- Werner Syfrig
- Patryk Szczerbinski
- Jules Szymkowiak